Publications

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1. Kwak, EL, Bang, YJ, Camidge, DR, Shaw, AT, Solomon, B, Maki, RG, Ou, SH, Dezube, BJ, Janne, PA, Costa, DB, Varella-Garcia, M, Kim, WH, Lynch, TJ, Fidias, P, Stubbs, H, Engelman, JA, Sequist, LV, Tan, W, Gandhi, L, Mino-Kenudson, M, Wei, GC, Shreeve, SM, Ratain, MJ, Settleman, J, Christensen, JG, Haber, DA, Wilner, K, Salgia, R, Shapiro, GI, Clark, JW, and Iafrate, AJ. Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. N Engl J Med. 2010 363(18):1693-1703. PMC3014291

2. Bergethon, K, Shaw, AT, Ignatius Ou, SH, Katayama, R, Lovly, CM, McDonald, NT, Massion, PP, Siwak-Tapp, C, Gonzalez, A, Fang, R, Mark, EJ, Batten, JM, Chen, H, Wilner, KD, Kwak, EL, Clark, JW, Carbone, DP, Ji, H, Engelman, JA, Mino-Kenudson, M, Pao, W, and Iafrate, AJ. ROS1 Rearrangements Define a Unique Molecular Class of Lung Cancers. J Clin Oncol. 2012. PMC3295572

3. Shaw AT, Ou SH, Bang YJ, Camidge DR, Solomon B, Salgia R, Riely GJ, Varella-Garcia M, Shapiro GI, Costa DB, Doebele RC, Le LP, Zheng Z, Tan W, Stephenson P, Shreeve SM, Tye LM, Christensen JG, Wilner K, Clark JW, Iafrate AJ: Crizotinib in ROS1-Rearranged Non-Small Cell Lung Cancer. N Engl J Med. Sept. 27, 2014. PMC4264527

4. Heist, RS, Shim, HS, Gingipally, S, Mino-Kenudson, M, Le, L, Gainor, JF, Zheng, Z, Aryee, M, Xia, J, Jia, P, Jin, H, Zhao, Z, Pao, W, Engelman, JA, and Iafrate, AJ. MET Exon 14 Skipping in Non-Small Cell Lung Cancer. Oncologist. 2016 21(4):481-486. PMC4828128

5. Dias-Santagata, D, Akhavanfard, S, David, SS, Vernovsky, K, Kuhlmann, G, Boisvert, SL, Stubbs, H, McDermott, U, Settleman, J, Kwak, EL, Clark, JW, Isakoff, SJ, Sequist, LV, Engelman, JA, Lynch, TJ, Haber, DA, Louis, DN, Ellisen, LW, Borger, DR, and Iafrate, AJ. Rapid targeted mutational analysis of human tumours: a clinical platform to guide personalized cancer medicine. EMBO Mol Med. 2010 2(5):146-158. PMC3377316

6. Zheng Z, Liebers M, Zhelyazkova B, Cao Y, Panditi D, Chen J, Robinson HE, Chmielecki J, Pao W, Engelman JA, Iafrate AJ*, Le LP*: Anchored multiplex PCR for targeted next-generation sequencing. Nat Medicine. Nov. 10 2014

7. Lih, CJ, Harringtion, RD, Sims, DJ, Harper, KN, Bouk, CH, Datta, V, Yau, J, Singh, RR, Routbort, MJ, Luthra, R, Patel, KP, Mantha, GS, Krishnamurthy, S, Ronski, K, Walther, Z, Finber, KE, Canosa, S, Robinson, H, Raymond, A, Le, LP, McShane, LM, Poley, EC, Conley, BA, Doroshow, JH, Iafrate, AJ, Sklar, JL, Hamilton, SR, and Williams, PR. Analytical Validation of the Next-Generation Sequencing Assay for a Nationwide Signal-Finding Clinical Trail: Molecular Analysis for Therapy Choice Clinical Trail. J Mol Diagn 2017 19(2):313-327. PMC5397672

8. Cheng J, Cao Y, MacLeay A, Lennerz JK, Baig A, Frazier RP, Lee J, Hu K, Pacula M, Meneses E, Robinson H, Batten JM, Brastianos PK, Heist RS, Bardia A, Le LP, Iafrate AJ. Clinical validation of a cell-free DNA gene panel. J Mol Diagn. 2019 Apr 23

9. Dienstmann, R, Dong, F, Borger, D, Dias-Santagata, D, Ellisen, LW, Le, LP, and Iafrate, AJ. Standardized decision support in next generation sequencing reports of somatic cancer variants. Mol Oncol. 2014 8(5):859-873

10. Yagi, Y, Riedlinger, G, Xu, X, Nakamura, A, Levy, B, Iafrate, AJ, Mino-Kenudson, M, and Klepeis, VE. Development of a database system and image viewer to assist in the correlation of histopathologic features and digital image analysis with clinical and molecular genetic information. Pathol Inf. 2016 66(2):63-74. PMC5528527

11. Lennerz JK, McLaughlin HM, Baron JM, Rasmussen D, Sumbada Shin M, Berners-Lee N, Miller Batten J, Swoboda KJ, Gala MK, Winter HS, Schmahmann JD, Sweetser DA, Boswell M, Pacula M, Stenzinger A, Le LP, Hynes W, Rehm HL, Klibanski A, Black-Schaffer SW, Golden JA, Louis DN, Weiss ST, Iafrate AJ. Health Care Infrastructure for Financially Sustainable Clinical Genomics. J Mol Diagn. 2016 Sep;18(5):697-706

12. Zomnir MG, Lipkin L, Pacula M, Meneses ED, MacLeay A, Duraisamy S, Nadhamuni N, Al Turki SH, Zeng Z, Rivera M, Nardi V, Dias-Santagata D, Iafrate AJ, Le LP, Lennerz JK. Artificial Intelligence Approach for Variant Reporting. JCO Clin Cancer Inform. 2018 (2) PMC6198661

13. Iafrate, AJ, Feuk, L, Rivera, MN, Listewnik, ML, Donahoe, PK, Qi, Y, Scherer, SW, and Lee, C. Detection of large-scale variation in the human genome. Nat Genet. 2004 36(9):949-951

14. Wu, D, Vu, Q, Nguyen, A, Stone, JR, Stubbs, H, Kuhlmann, G, Sholl, LM, and Iafrate, AJ. In situ genetic analysis of cellular chimerism. Nat Med. 2009 15(2):215-219

15. Adar, T, Rodgers, LH, Shannon, KM, Yoshida, M, Ma, T, Mattia, A, Lauwers, GY, Iafrate, AJ, and Chung, DC. A tailored approach to BRAF and MLH1 methylation testing in a universal screening program for Lynch Syndrome. Mod Pathol 2017 30(3):440-447

16. Onozato ML, Yapp C, Richardson D, Sundaresan T, Chahal V, Lee J, Sullivan JP, Madden MW, Shim HS, Liebers M, Ho Q, Maheswaran S, Haber DA, Zheng Z, Clancy B, Elliott HL, and Iafrate AJ. Highly Multiplexed FISH for In Situ Genomics. J. Mol. Diagnostics, 2019

17. Thierauf J, Ramamurthy N, Jo VY, Robinson H, Frazier RP, Gonzalez J, Pacula M, Dominguez Meneses E, Nose V, Nardi V, Dias-Santagata D, Le LP, Lin DT, Faquin WC, Wirth LJ, Hess J, Iafrate AJ, Lennerz JK. Clinically Integrated Molecular Diagnostics in Adenoid Cystic Carcinoma, Oncologist. 2019 Oct;24(10):1356-1367